| Date | Opponent | Location | TV | Outcome/Time |
| 11/09/2000 | LKKA Kaunas(Exh.) | Charlotte, N.C. | W, 77-61 Recap | Stats | |
| 11/13/2000 | Supreme Court (Exh.) | Charlotte, N.C. | L, 67-59 Recap | Stats | |
| 11/17/2000 | Massachusetts | Amherst, Mass. | L, 64-48 Recap | Stats | |
| 11/20/2000 | UNC Greensboro | Greensboro, N.C. | L, 81-70 Recap | Stats | |
| 11/24/2000 | vs. St. John's | Las Vegas (UNLV Rebel Shootout) | W, 71-68 Recap | Stats | |
| 11/25/2000 | vs. UNLV | Las Vegas (UNLV Rebel Shootout) | L, 60-55 Recap | Stats | |
| 11/29/2000 | Duke | Durham, N.C. | L, 78-59 Recap | Stats | |
| 12/02/2000 | Furman | Charlotte, N.C. (DH w/ men) | L, 58-55 Recap | Stats | |
| 12/06/2000 | Appalachian State | Charlotte, N.C. (DH w/ men) | W, 71-58 Recap | Stats | |
| 12/09/2000 | South Carolina State | Charlotte, N.C. | W, 76-61 Recap | Stats | |
| 12/18/2000 | Davidson | Davidson, N.C. | W, 77-67 Recap | Stats | |
| 12/28/2000 | South Carolina | Charlotte, N.C. | L, 61-43 Recap | Stats | |
| 12/31/2000 | Saint Louis* | St. Louis, Mo. | L, 58-49 Recap | Stats | |
| 01/05/2001 | Southern Miss* | Charlotte, N.C. | L, 74-72 Recap | Stats | |
| 01/07/2001 | Tulane* | New Orleans, La. | L, 78-64 Recap | Stats | |
| 01/14/2001 | Saint Louis* | Charlottte, N.C. | W, 49-45 Recap | Stats | |
| 01/19/2001 | Louisville* | Louisville, Ky. | L, 69-51 Recap | Stats | |
| 01/21/2001 | Cincinnati* | Cincinnati, Ohio | L, 69-48 Recap | Stats | |
| 01/26/2001 | Marquette* | Charlotte, N.C. | L, 57-55 Recap | Stats | |
| 01/28/2001 | DePaul* | Charlotte, N.C. | W, 80-65 Recap | Stats | |
| 01/31/2001 | Winthrop | Charlotte, N.C. | W, 64-48 Recap | Stats | |
| 02/02/2001 | Houston* | Charlotte, N.C. | W, 70-58 Recap | Stats | |
| 02/04/2001 | South Florida* | Charlotte, N.C. | W, 50-45 Recap | Stats | |
| 02/09/2001 | UAB* | Birmingham, Ala. | L, 69-67 Recap | Stats | |
| 02/11/2001 | Memphis* | Memphis, Tenn. | L, 76-71 Recap | Stats | |
| 02/16/2001 | Cincinnati* | Charlotte, N.C. | L, 73-50 Recap | Stats | |
| 02/18/2001 | Louisville* | Charlotte, N.C. | W, 58-52 Recap | Stats | |
| 02/23/2001 | DePaul* | Chicago, Ill. | L, 59-58 Recap | Stats | |
| 02/25/2001 | Marquette* | Milwaukee, Wis. | L, 46-35 Recap | Stats | |
| 03/02/2001 | Marquette | Milwaukee, Wis. | L, 76-65 Recap | Stats |