| Date | Opponent | Location | TV | Outcome/Time |
| 02/01/2001 | High Point | High Point, N.C. | L, 8-5 Recap | Stats | |
| 02/06/2001 | Furman | Greenville, S.C. | W, 6-4 Recap | Stats | |
| 02/09/2001 | Southwest Texas (Round Rock Express Tournament) | Round Rock, TX | L, 7-6 Recap | Stats | |
| 02/10/2001 | TCU (Round Rock Express Tournament) | Round Rock, TX | L, 10-1 Recap | Stats | |
| 02/11/2001 | Kansas (Round Rock Express Tournament) | Round Rock, TX | L, 5-2 Recap | Stats | |
| 02/17/2001 | Penn State | Charlotte, N.C. | L, 7-2 Recap | Stats | |
| 02/18/2001 | Penn State | Charlotte, N.C. | W, 4-3 Recap | Stats | |
| 02/20/2001 | Wake Forest | Winston Salem, N.C. | L, 17-8 Recap | Stats | |
| 02/23/2001 | George Washington | Charlotte, N.C. | W, 7-1 Recap | Stats | |
| 02/24/2001 | George Washington | Charlotte, N.C. | W, 5-4 Recap | Stats | |
| 02/28/2001 | UNC Greensboro | Charlotte, N.C. | W, 14-1 Recap | Stats | |
| 03/07/2001 | UNC Wilmington | Charlotte, N.C. | W, 7-5 Recap | Stats | |
| 03/08/2001 | UNC Wilmington | Charlotte, N.C. | L, 13-0 Recap | Stats | |
| 03/10/2001 | Old Dominion | Norfolk, Va | L, 9-5 Recap | Stats | |
| 03/11/2001 | Old Dominion | Norfolk, Va | L, 19-9 Recap | Stats | |
| 03/13/2001 | UNC Asheville | Charlotte, N.C. | W, 14-7 Recap | Stats | |
| 03/17/2001 | Memphis | Charlotte, N.C. | L, 12=8 Recap | Stats | |
| 03/17/2001 | Memphis | Charlotte, N.C. | W, 5-2 Stats | |
| 03/18/2001 | Memphis | Charlotte, N.C. | W, 6-5 Recap | Stats | |
| 03/23/2001 | Southern Miss | Hattiesburg, Miss | L, 5-2 Recap | Stats | |
| 03/24/2001 | Southern Miss | Hattiesburg, Miss | L, 11-10 (10 inn.) Recap | Stats | |
| 03/25/2001 | Southern Miss | Hattiesburg, Miss | W, 5-2 Recap | Stats | |
| 03/27/2001 | Appalachian State | Charlotte, N.C. | W, 13-4 Recap | Stats | |
| 03/30/2001 | UAB | Birmingham, Ala. | L, 13-6 Recap | Stats | |
| 03/31/2001 | UAB | Birmingham, Ala. | W, 5-4 Recap | Stats | |
| 04/01/2001 | UAB | Birmingham, Ala. | W, 5-2 Recap | Stats | |
| 04/04/2001 | N.C. State | Raleigh, N.C. | L, 6-2 Recap | Stats | |
| 04/06/2001 | Tulane | Charlotte, N.C. | L, 8-6 Recap | Stats | |
| 04/07/2001 | Tulane | Charlotte, NC | L, 12-4 Recap | Stats | |
| 04/08/2001 | Tulane | Charlotte, NC | L, 18-4 Recap | Stats | |
| 04/10/2001 | Appalachian State | Boone, N.C. | W, 8-6 Recap | Stats | |
| 04/11/2001 | North Carolina | Chapel Hill, N.C. | L, 4-1 Recap | Stats | |
| 04/13/2001 | Louisville | Charlotte, N.C. | L, 14-9 Recap | Stats | |
| 04/14/2001 | Louisville | Charlotte, N.C. | L, 7-5 Recap | Stats | |
| 04/15/2001 | Louisville | Charlotte, N.C. | W, 7-4 Recap | Stats | |
| 04/17/2001 | High Point | Charlotte, N.C. | W, 11-10 (10 inn.) Recap | Stats | |
| 04/20/2001 | Houston | Houston, Texas | L, 12-2 Recap | Stats | |
| 04/21/2001 | Houston | Houston, Texas | L, 10-4 Recap | Stats | |
| 04/22/2001 | Houston | Houston, Texas | L, 6-2 Recap | Stats | |
| 04/25/2001 | Wake Forest | Charlotte, NC | W, 1-0 Recap | Stats | |
| 04/25/2001 | Wake Forest | Charlotte, N.C. | L, 11-7 Stats | |
| 04/27/2001 | Cincinnati | Cincinnati, Ohio | L, 13-7 Recap | Stats | |
| 04/28/2001 | Cincinnati | Cincinnati, Ohio | L, 13-0 Recap | Stats | |
| 04/29/2001 | Cincinnati | Cincinnati, Ohio | L, 10-4 Recap | Stats | |
| 05/02/2001 | Furman | Charlotte, N.C. | W, 9-7 Recap | Stats | |
| 05/04/2001 | South Florida | Charlotte, N.C. | L, 7-2 Recap | Stats | |
| 05/05/2001 | South Florida | Charlotte, N.C. | W, 7-1 Recap | Stats | |
| 05/06/2001 | South Florida | Charlotte, N.C. | W, 5-4 (11) Recap | Stats | |
| 05/09/2001 | Elon | Charlotte, N.C. | W, 4-2 Recap | Stats | |
| 05/11/2001 | Saint Louis | St. Louis, Mo. | W, 13-2 Recap | Stats | |
| 05/12/2001 | Saint Louis | St. Louis, Mo. | L, 12-9 Recap | Stats | |
| 05/13/2001 | Saint Louis | St. Louis, Mo. | W, 6-1 Recap | Stats | |
| 05/16/2001 | Tulane | New Orleans, La. (Zephyr Field) | W, 8-4 Recap | Stats | |
| 05/17/2001 | Memphis | New Orleans, La. (Zephyr Field) | L, 4-2 Recap | Stats | |
| 05/18/2001 | Tulane | New Orleans, La. (Zephyr Field) | L, 6-2 Recap | Stats |